Daily Shaarli

All links of one day in a single page.

March 4, 2020

Bloomberg Lost, But He May Still Get What He Wanted | FiveThirtyEight
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He got to go on stage in the debates and attack Sanders and Warren. We don’t know if that boosted Biden, but it likely didn’t hurt him. With Biden now in a much stronger position than when Bloomberg entered the race, you could argue that Bloomberg provided what he and other more center-left figures wanted — to steer the race towards a more moderate nominee.

He hired people in numerous states for his presidential campaign, and his employees were reportedly told that they would have jobs through November. It’s not clear if Bloomberg will end up retaining these staffers for some kind of operation to boost Biden against Sanders and Warren in the primary, have his team start focusing now on the general election against Trump or simply wind down his apparatus. But I expect him to stay out of the primary and focus on Trump.

5 lessons about COVID-19 from doctor who led WHO mission to China | CBC Radio
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"It's not a cold. It's not a runny nose. It's not a sore throat. Those are relatively rare symptoms in COVID," he said.

Poll: Most Americans want universal healthcare but don't want to abolish private insurance | TheHill
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A new poll finds that about only one in 10 registered voters want the equivalent of Medicare for all if it means abolishing private health insurance plans.

Report of the WHO-China Joint Mission on Coronavirus Disease

As of 20 February 2020 and 12 based on 55924 laboratory confirmed cases, typical signs and symptoms include: fever (87.9%), dry cough (67.7%), fatigue (38.1%), sputum production (33.4%), shortness of breath (18.6%), sore throat (13.9%), headache (13.6%), myalgia or arthralgia (14.8%), chills (11.4%), nausea or vomiting (5.0%), nasal congestion (4.8%), diarrhea (3.7%), and hemoptysis (0.9%),
and conjunctival congestion (0.8%).

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018 | Drug Development | JAMA | JAMA Network

Question How much do drug companies spend on research and development to bring a new medicine to market?

Findings In this study, which included 63 of 355 new therapeutic drugs and biologic agents approved by the US Food and Drug Administration between 2009 and 2018, the estimated median capitalized research and development cost per product was $985 million, counting expenditures on failed trials. Data were mainly accessible for smaller firms, products in certain therapeutic areas, orphan drugs, first-in-class drugs, therapeutic agents that received accelerated approval, and products approved between 2014 and 2018.

How do people react to a threat like coronavirus? It depends on anxiety and sensitivity to fear - The Globe and Mail
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In reckless individuals, the researchers found that a part of the brain involved in assessing whether there is enough information, called the inferior frontal gyrus, was atrophied. Thus, their brain signals did not trigger information-seeking behaviour, she says.

How the Top Democratic Candidates’ Healthcare Plans Measure Up

All of the candidates are proposing big improvements to healthcare — but experts are critical of their plans to pay for it.

Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies | Drug Development | JAMA | JAMA Network

Question How do the profits of large pharmaceutical companies compare with those of other companies from the S&P 500 Index?

Findings In this cross-sectional study that compared the profits of 35 large pharmaceutical companies with those of 357 large, nonpharmaceutical companies from 2000 to 2018, the median net income (earnings) expressed as a fraction of revenue was significantly greater for pharmaceutical companies compared with nonpharmaceutical companies (13.8% vs 7.7%).

Meaning Large pharmaceutical companies were more profitable than other large companies, although the difference was smaller when controlling for differences in company size, research and development expense, and time trends.

Coronavirus in China: The most important lessons from China’s Covid-19 response - Vox
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most of the measures used in China to stop the virus were traditional public health moves that are broadly accepted — and the draconian measures were rarer.

I think the key learning from China is speed — it’s all about the speed. The faster you can find the cases, isolate the cases, and track their close contacts, the more successful you’re going to be.

Since coming back from China, everybody I talk to begins with, “We can’t lock down a city of 15 million people like China.” I say, “Why would you ever want to?” And I ask, “Does your population know x, y, z [about the virus]?” I learn they haven’t started with the basics.

So, No. 1, if you want to get speed of response, your population has to know this disease. You find any population in the West and ask them what are the two presenting signs you have to be alert to. ... the two initial symptoms most common [are] fever and dry cough... [But many still think] it’s a runny nose and cold. Your population is your surveillance system. Everybody has got a smartphone, everybody can get a thermometer. That is your surveillance system. Don’t rely on this hitting your health system, because then it’s going to infect it.

the key is public information and having an informed population, finding those cases, rapidly isolating them. The faster you isolate them is what breaks the chains. Making sure close contacts are quarantined and monitored until you know if they’re infected. Somewhere between 5 and 15 percent of those contacts are infected. And again, it’s the close contacts, not everyone.

China took a whole bunch of steps when they realized they had to repurpose big chunks of their hospital systems to [respond to the outbreak]. The first thing is, they said testing is free, treatment is free. Right now, there are huge barriers [to testing and treatment] in the West. You can get tested, but then you might be negative and have to foot the bill. In China, they realized those were barriers to people seeking care, so, as a state, they took over the payments for people whose insurance plans didn’t cover them. They tried to mitigate those barriers.

The other thing they did: Normally a prescription in China can’t last for more than a month. But they increased it to three months to make sure people didn’t run out [when they had to close a lot of their hospitals]. Another thing: Prescriptions could be done online and through WeChat [instead of requiring a doctor appointment]. And they set up a delivery system for medications for affected populations.

People keep saying [the cases are the] tip of the iceberg. But we couldn’t find that. We found there’s a lot of people who are cases, a lot of close contacts — but not a lot of asymptomatic circulation of this virus in the bigger population. And that’s different from flu. In flu, you’ll find this virus right through the child population, right through blood samples of 20 to 40 percent of the population.

Originally, I was a big believer in the idea that we should swab millions and see what’s going on [how many have the virus]. But the data from China made me rethink that. What could be done instead is that every hospital should test people with atypical pneumonia for Covid. People with flu-like symptoms — test for Covid.

Panic and hysteria are not appropriate. This is a disease that is in the cases and their close contacts. It’s not a hidden enemy lurking behind bushes. Get organized, get educated, and get working.